Chemical characterization and bioactivities assessment of Artemisia herba-alba Asso essential oil from South-western Algeria

Artemisia herba-alba Asso is a medicinal plant used widely in Algerian folk medicine for the treatment of several diseases. The present work aimed to elucidate chemical composition essential oil (EO) herba-alba. vitro antibacterial activity against 11 bacterial strains, and vivo acute toxicity anti-inflammatory were evaluated. In this study fifty-four compounds accounting 94.1% total identified by GC-FID GC-MS analysis obtained from leaves. α-thujone (48.0%), β-thujone (13.4%), camphor (13.1%) are found be major compounds. results using disc diffusion method revealed inhibition zones ranging 10.00±0.0 36.00±0.9mm. Gram-positive was more sensitive EO compared with Gram-negative bacteria. exhibited minimum inhibitory concentrations bactericidal 2.5 mg/ml 10 mg/ml, 5 respectively. moderately toxic belongs category 4 according GHS, mortality achieved at dose 2000 mg/kg. A. reduced significantly edema induced carrageenan rat paw 44.07% 44.37% (after five hours) doses 50 mg/kg 100